MMP3 Antibody (YA6247)

MMP3 Antibody (YA6247) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP3. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

MMP3 is a metalloproteinase with broad substrate specificity, capable of degrading fibronectin, laminin, gelatins of types I, III, IV, and V, as well as collagens III, IV, X, and IX, and cartilage proteoglycans. It activates various molecules, including growth factors, plasminogen, or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. MMP3 also functions intracellularly—for example, in dopaminergic neurons, it is activated by the serine protease HTRA2 under stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. Additionally, it contributes to immune responses and exhibits antiviral activity against viruses like vesicular stomatitis virus, influenza A virus (H1N1), and human herpes virus 1. Mechanistically, upon viral infection, it translocates from the cytoplasm to the nucleus to modulate NF-kappa-B activities.

P08254

Predicted band size: 54 kDa; Observed band size: 54 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:200-1:1000; WB: 1:1000-1:5000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG