2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. MBNL1 Antibody (YA2601)

MBNL1 Antibody (YA2601)

Cat. No.: HY-P82856
User Guide for Antibodies Technical Support

MBNL1 Antibody (YA2601) is a non-conjugated IgG antibody, targeting MBNL1, with a predicted molecular weight of 42 kDa (observed band size: 42 kDa). MBNL1 Antibody (YA2601) can be used for WB experiment in human, mouse background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
Synthetic products have potential research and development risk.
or Bulk Inquiry

* Please select Quantity before adding items.

Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

MBNL1 Antibody (YA2601) is a non-conjugated IgG antibody, targeting MBNL1, with a predicted molecular weight of 42 kDa (observed band size: 42 kDa). MBNL1 Antibody (YA2601) can be used for WB experiment in human, mouse background.
Background

MBNL1 is an RNA-binding protein that mediates pre-mRNA alternative splicing regulation, functioning as either an activator or repressor for specific pre-mRNA targets. In muscle tissue, it inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion while promoting insulin receptor (IR) pre-mRNA exon inclusion. It regulates TNNT2 exon 5 skipping by competing with U2AF2 and binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly, thereby inhibiting the formation of the spliceosomal A complex on TNNT2 pre-mRNA intron 4. MBNL1 recognizes the 5'-YGCU(U/G)Y-3' consensus sequence and binds to IR RNA as well as expanded CUG repeat RNA (which forms a hairpin structure with GC base pairs and bulged, unpaired U residues). It cooperates with RNA-binding proteins RBPMS and RBFOX2 to activate alternative splicing events in vascular smooth muscle cells. Additionally, MBNL1 regulates NCOR2 alternative splicing (By similarity).
Gene ID
SwissProt ID
Synonyms
EXP; EXP35; EXP40; EXP42; MBNL; MBNL1
Molecular Weight

Predicted band size: 42 kDa; Observed band size: 42 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

-
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse
Dilution Ratio

WB: 1/500-1/1000
Application

WB
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human MBNL1
Database

Entrez Gene: 4154 Human ; 56758 Mouse ; 282635 Rat

SwissProt: Q9NR56 Human ; Q9JKP5 Mouse ;

OMIM: 160900 Human

Documentation
User Guide for Antibodies (1077 KB)

MBNL1 Antibody (YA2601) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MBNL1 Antibody (YA2601)
Cat. No.:
HY-P82856
Quantity:
MCE Japan Authorized Agent:

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Country or Region *

Email Address *

     

Phone Number *

 

Organization Name *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.