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  5. MBNL1 Antibody (YA2601)

MBNL1 Antibody (YA2601)

Cat. No.: HY-P82856
User Guide for Antibodies Technical Support

MBNL1 Antibody (YA2601) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MBNL1.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

MBNL1 Antibody (YA2601) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MBNL1.
Background

MBNL1 is an RNA-binding protein that mediates pre-mRNA alternative splicing regulation, functioning as either an activator or repressor for specific pre-mRNA targets. In muscle tissue, it inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion while promoting insulin receptor (IR) pre-mRNA exon inclusion. It regulates TNNT2 exon 5 skipping by competing with U2AF2 and binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly, thereby inhibiting the formation of the spliceosomal A complex on TNNT2 pre-mRNA intron 4. MBNL1 recognizes the 5'-YGCU(U/G)Y-3' consensus sequence and binds to IR RNA as well as expanded CUG repeat RNA (which forms a hairpin structure with GC base pairs and bulged, unpaired U residues). It cooperates with RNA-binding proteins RBPMS and RBFOX2 to activate alternative splicing events in vascular smooth muscle cells. Additionally, MBNL1 regulates NCOR2 alternative splicing (By similarity).
Gene ID
SwissProt ID
Synonyms
EXP; EXP35; EXP40; EXP42; MBNL; MBNL1
Molecular Weight

Predicted band size: 42 kDa; Observed band size: 42 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

-
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse
Dilution Ratio

WB: 1:500-1:1000
Application

WB
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human MBNL1
Database

Entrez Gene: 4154 Human ; 56758 Mouse ; 282635 Rat

SwissProt: Q9NR56 Human ; Q9JKP5 Mouse ;

OMIM: 160900 Human

Documentation
User Guide for Antibodies (1077 KB)

MBNL1 Antibody (YA2601) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MBNL1 Antibody (YA2601)
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HY-P82856
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