MEK2 Antibody (YA3980)

MEK2 Antibody (YA3980) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MEK2.

MEK1 protein, a pivotal component of the MAP kinase signal transduction pathway, plays a crucial role in transducing extracellular signals into intracellular responses. Upon binding of ligands such as growth factors and cytokines to their cell-surface receptors, MEK1 is activated as part of the RAS-RAF1-MEK1/2-MAPK/ERK cascade. MEK1, along with MAP2K2/MEK2, catalyzes the dual phosphorylation of threonine and tyrosine residues in the activation loop of ERK1 and ERK2, thereby initiating downstream signaling events. This cascade regulates diverse biological functions, including cell growth, adhesion, survival, and differentiation. In addition to its role in the transcriptional and cytoskeletal regulation, the MAPK/ERK pathway impacts peroxisome proliferator-activated receptor gamma (PPARG), contributing to cellular processes such as differentiation and apoptosis. Furthermore, MEK1's involvement in endosomal dynamics and Golgi apparatus fragmentation during mitosis underscores its versatility in coordinating intricate cellular responses.

P36507

Predicted band size: 44 kDa; Observed band size: 44 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal Antibody

Mouse

Human, Mouse, Rat

WB: 1:500-1:2000; IF: 1:200-1:1000; FC: 1:200-1:400; ELISA: 1:10000

WB, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human MAP2K2 full(aa 1-400).