LKB1 Antibody (YA4952)

LKB1 Antibody (YA4952) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to LKB1.

LKB1 is a tumor suppressor serine/threonine-protein kinase that regulates AMP-activated protein kinase (AMPK) family members, playing pivotal roles in cell metabolism, polarity, apoptosis, and DNA damage response. It activates AMPK family proteins (e.g., PRKAA1, PRKAA2, BRSK1, BRSK2) via T-loop phosphorylation and also targets non-AMPK proteins like STRADA, PTEN, and potentially p53/TP53. As a master upstream regulator of AMPK, LKB1 phosphorylates PRKAA1/PRKAA2 to inhibit growth signaling under energy stress, maintain hepatic glucose homeostasis, induce nutrient-deprivation autophagy, and mediate germinal center B-cell differentiation. In cell polarity, LKB1 remodels the actin cytoskeleton by activating BRSK1/BRSK2 for axon initiation in cortical neurons. During DNA damage response, LKB1 interacts with p53/TP53 at the CDKN1A/WAF1 promoter for transcriptional activation and may indirectly phosphorylate p53 via NUAK1. Collaborating with NUAK1, LKB1 phosphorylates CDKN1A post-UV radiation to facilitate its degradation for efficient DNA repair. It also mediates p53-dependent apoptosis through mitochondrial translocation and participates in spermiogenesis.

Q15831

Predicted band size: 49 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Monkey

WB: 1:500-1:2000; FC: 1:200-1:400; ELISA: 1:10000

WB, FC, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human LKB1 expressed in E. Coli.