Leptin Antibody (YA5310)

Leptin Antibody (YA5310) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Leptin. It can be applicated for ELISA assays, in the background of human.

Leptin, a pivotal regulator of energy balance and body weight, exerts central and peripheral effects upon binding to its receptor, LEPR, distributed across various tissues. In the hypothalamus, Leptin acts as an appetite-regulating factor, decreasing food intake and increasing energy consumption by modulating anorexinogenic and orexigenic neuropeptides. Additionally, it influences bone mass, hypothalamo-pituitary-adrenal hormone secretion, and reproductive function. In peripheral tissues, Leptin enhances basal metabolism, regulates pancreatic beta-cell function and insulin secretion, and exhibits pro-angiogenic effects on endothelial cells, impacting both innate and adaptive immunity. Within the hypothalamic arcuate nucleus, Leptin activates POMC neurons, releasing anorexigenic peptides upon depolarization, and inhibits NPY neurons upon hyperpolarization, reducing the release of orexigenic peptides. Beyond its role in satiety, Leptin modulates nutrient absorption in the intestine by inhibiting glucose absorption through PKC activation and subsequent signaling pathways. Leptin also acts as a growth factor, influencing cell cycle regulation and gene expression. Moreover, it plays a role in apoptosis, angiogenesis, and immune responses, exhibiting pro-inflammatory effects and promoting T helper-1 cell immune responses in adaptive immunity. Leptin's multifaceted functions highlight its intricate involvement in maintaining energy homeostasis and coordinating various physiological processes.

P41159

Observed band size: 16 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

ELISA: 1:10000-20000

ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant full length of human Leptin protein expressed in E.coli.