LAMP1 Antibody (YA6213)

LAMP1 Antibody (YA6213) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LAMP1. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human.

LAMP1 is a lysosomal membrane glycoprotein that plays crucial roles in lysosome biogenesis, lysosomal pH regulation, autophagy, and cholesterol homeostasis. It acts as a key regulator of lysosomal lumen pH by directly inhibiting the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. LAMP1 is also essential for NK-cell cytotoxicity, participating in cytotoxic granule movement to the cell surface and perforin trafficking to lytic granules, while protecting NK-cells from degranulation-associated damage caused by their own cytotoxic granule content. Additionally, LAMP1 presents carbohydrate ligands to selectins. In microbial infections, it serves as a receptor for the Lassa virus glycoprotein and promotes virus-host membrane fusion in less acidic endosomes. By similar function, LAMP1 supports FURIN-mediated cleavage of the mumps virus fusion protein F by interacting with both FURIN and the unprocessed form of the viral protein F.

P11279

Predicted band size: 45 kDa; Observed band size: 100 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human

IHC: 1:200-1:1000; WB: 1:1000-1:5000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200,

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG