LAMP1 Antibody (YA3755)

LAMP1 Antibody (YA3755) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LAMP1.

LAMP1 is a lysosomal membrane glycoprotein that plays crucial roles in lysosome biogenesis, lysosomal pH regulation, autophagy, and cholesterol homeostasis. It acts as a key regulator of lysosomal lumen pH by directly inhibiting the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. LAMP1 is also essential for NK-cell cytotoxicity, participating in cytotoxic granule movement to the cell surface and perforin trafficking to lytic granules, while protecting NK-cells from degranulation-associated damage caused by their own cytotoxic granule content. Additionally, LAMP1 presents carbohydrate ligands to selectins. In microbial infections, it serves as a receptor for the Lassa virus glycoprotein and promotes virus-host membrane fusion in less acidic endosomes. By similar function, LAMP1 supports FURIN-mediated cleavage of the mumps virus fusion protein F by interacting with both FURIN and the unprocessed form of the viral protein F.

P11279

Predicted band size: 45 kDa; Observed band size: 45/110 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal Antibody

Mouse

Human, Mouse, Monkey

WB: 1:500-1:2000; IHC: 1:200-1:1000; IF: 1:200-1:1000; FC: 1:200-1:400; ELISA: 1:10000

WB, IHC-P, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human LAMP1 (AA: 182-414) expressed in E. Coli.