Lamin A/C Antibody (YA314)

Cat. No.: HY-P80204: Data Sheet COA
SDS
User Guide for Antibodies
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Technical Support

Lamin A/C Antibody is a non-conjugated and Rabbit origined IgG monoclonal antibody, targeting to Lamin A/C. It can be used as a loading control antibody.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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Lamin A/C Antibody (YA314) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
Technical Parameters
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Description	Lamin A/C Antibody is a non-conjugated and Rabbit origined IgG monoclonal antibody, targeting to Lamin A/C. It can be used as a loading control antibody.
Background	Lamin A is an intermediate filament protein that, along with Lamin C (by similar), forms the major components of the nuclear lamina, a fibrous meshwork on the nucleoplasmic side of the inner nuclear membrane. It provides structural support by bridging the nuclear envelope and chromatin, playing pivotal roles in nuclear assembly, chromatin organization, nuclear membrane dynamics, and telomere maintenance. Lamin A/C regulates nuclear mechanical properties to influence matrix stiffness, with its structural integrity tightly controlled during cell cycle progression (e.g., disassembly in prophase and reassembly in telophase). Mammalian lamina contains equal amounts of Lamin A and C. The protein participates in DNA repair by being recruited to double-strand breaks by XRCC4 and IFFO1 to immobilize broken DNA ends, preventing chromosomal translocations. It is essential for peripheral nervous system development, skeletal muscle formation, muscle satellite cell proliferation (by similar: osteoblastogenesis and bone formation while preventing fat infiltration into muscle/bone marrow to maintain tissue integrity). Cardiac homeostasis requires Lamin A/C, though prelamin-A/C may promote vascular smooth muscle cell senescence via mitotic disruption and DNA damage-induced genomic instability.
Tag	Free
Gene ID	4000 [NCBI]
SwissProt ID	P02545
Molecular Weight	Predicted band size: 74 kDa; Observed band size: 70/65 kDa
Purity	Protein A affinity purified.
Subcellular Location	Intermediate filament, Nucleus.
Conjugation	Non-conjugated
Modification	Unmodified
RRID	AB_3102347
Research Field	Tags & Cell Markers
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Mouse, Rat
Dilution Ratio	WB: 1:500-1:2,000 ;ICC: 1:50-1:100 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Application	WB, ICC/IF, IHC-P, FC
Appearance	Liquid
Formulation	Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	Synthetic peptide corresponding to Human Lamin A/C.AA range:191-309.
Database	Entrez Gene: 4000 Human ; 16905 Mouse ; SwissProt: P02545 Human ; P48678 Mouse ; P48679 Rat OMIM: 181350 Human
Documentation	Select Batch: Data Sheet (235 KB) SDS (251 KB) COA (191 KB) User Guide for Antibodies (1077 KB)

Lamin A/C Antibody (YA314) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Lamin A/C Antibody (YA314)

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Biological Activity

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