KMT6/EZH2 Antibody (YA3032)

Cat. No.: HY-P83287: Data Sheet User Guide for Antibodies
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KMT6/EZH2 Antibody (YA3032) is a non-conjugated IgG antibody, targeting KMT6, with a predicted molecular weight of 85 kDa (observed band size: 98 kDa). KMT6/EZH2 Antibody (YA3032) can be used for WB experiment in human background.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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KMT6/EZH2 Antibody (YA3032) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

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Description	KMT6/EZH2 Antibody (YA3032) is a non-conjugated IgG antibody, targeting KMT6, with a predicted molecular weight of 85 kDa (observed band size: 98 kDa). KMT6/EZH2 Antibody (YA3032) can be used for WB experiment in human background.
Background	EZH2, a Polycomb group (PcG) protein, acts as the catalytic subunit of the PRC2/EED-EZH2 complex, contributing to histone methylation and subsequent transcriptional repression. This complex mono-, di-, and trimethylates 'Lys-27' (H3K27) of histone H3, generating H3K27me1, H3K27me2, and H3K27me3, respectively. EZH2 exhibits a preference for substrates with less methylation and is pivotal for forming H3K27me3 in embryonic stem cells, playing a crucial role in maintaining stem cell identity and facilitating proper differentiation. Moreover, the PRC2/EED-EZH2 complex may serve as a platform for recruiting DNA methyltransferases, establishing a connection between distinct epigenetic repression systems. Target genes repressed by this complex include HOXC8, HOXA9, MYT1, CDKN2A, and retinoic acid-responsive genes. EZH2 extends its methylating activity beyond histones to non-histone proteins like the transcription factor GATA4 and nuclear receptor RORA. Additionally, EZH2 regulates the circadian clock through histone methylation at circadian gene promoters, contributing to CRY1/2-mediated repression of CLOCK-BMAL1-driven transcriptional activation of PER1/2. This multifaceted involvement underscores EZH2's integral role in epigenetic regulation and cellular processes.
Gene ID	2146 [NCBI]
SwissProt ID	Q15910
Synonyms	WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; EZH2
Molecular Weight	Predicted band size: 85 kDa; Observed band size: 98 kDa
Purity	Affinity Purified
Conjugation	Non-conjugated
Modification	Unmodified
Research Field	Epigenetics and Nuclear Signaling
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human
Dilution Ratio	WB: 1/500-1/1000
Application	WB
Appearance	Liquid
Formulation	Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	Recombinant protein of human KMT6/EZH2
Database	Entrez Gene: 2146 Human SwissProt: Q15910 Human OMIM: 277590 Human
Documentation	Data Sheet (235 KB) User Guide for Antibodies (1077 KB)

KMT6/EZH2 Antibody (YA3032) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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KMT6/EZH2 Antibody (YA3032)

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