KAT2B Antibody (YA4403)

KAT2B Antibody (YA4403) is a mouse-derived and non-conjugated IgG1 antibody, targeting to KAT2B. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, rat, monkey.

KAT2B functions as a histone acetyltransferase (HAT) that promotes transcriptional activation. It exhibits significant histone acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles, with a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac). KAT2B also acetylates non-histone proteins, including ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K, and TBX5. It inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Additionally, KAT2B acts as a circadian transcriptional coactivator, enhancing the activity of NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers. In heart and limb development, it mediates TBX5 acetylation, regulating its nucleocytoplasmic shuttling. KAT2B negatively regulates centrosome amplification by acetylating PLK4 and impairs pre-rRNA processing by acetylating RRP9/U3-55K, a core subunit of the U3 snoRNP complex. It also promotes dynamic kinetochore-microtubule interactions in early mitosis by acetylating MAPRE1/EB1 and acetylates spermidine. During HIV-1 infection, KAT2B is recruited by the viral protein Tat, regulating Tat's transactivating activity and potentially aiding in chromatin remodeling of proviral genes.

Q92831

Predicted band size: 93 kDa; Observed band size: 95-110 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Mouse, Rat, Monkey

IHC: 1/200-1/1000; IF: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

WB, IHC-P, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human KAT2B (AA: 1-142) expressed in E. Coli.