JAK1 Antibody (YA331)

Cat. No.: HY-P80196: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

JAK1 Antibody (YA331) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to JAK1.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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JAK1 Antibody (YA331) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

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Description	JAK1 Antibody (YA331) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to JAK1.
Background	JAK1 protein, a non-receptor tyrosine kinase, plays a crucial role in the IFN-alpha/beta/gamma signal pathway, as evidenced by various studies. It acts as a kinase partner for the interleukin (IL)-2 receptor and IL-10 receptor, demonstrating its versatility in different cytokine signaling pathways. Moreover, JAK1 serves as a kinase partner for the type I interferon receptor IFNAR2, and upon interferon binding to the IFNAR1-IFNAR2 heterodimer, it phosphorylates and activates IFNAR2, creating docking sites for STAT proteins. JAK1 not only directly phosphorylates STAT proteins but also activates STAT signaling by transactivating other JAK kinases associated with signaling receptors. This multifaceted involvement positions JAK1 as a central player in the intricate network of signaling pathways, contributing to the regulation of immune responses and cellular processes.
Tag	Free
Gene ID	3716 [NCBI]
SwissProt ID	P23458
Molecular Weight	Predicted band size: 133 kDa; Observed band size: 133 kDa
Purity	Protein A affinity purified.
Subcellular Location	Endomembrane system.
Conjugation	Non-conjugated
Modification	Unmodified
RRID	AB_3102341
Research Field	Cell Biology
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Mouse, Rat
Dilution Ratio	WB: 1:500-1:1,000 ;IHC-P: 1:50-1:500 ;FC: 1:50-1:100
Application	WB, IHC-P, FC
Appearance	Liquid
Formulation	Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	Synthetic peptide corresponding to Human JAK1.AA range:621-670.
Database	Entrez Gene: 3716 Human ; 16451 Mouse ; 84598 Rat SwissProt: P23458 Human ; P52332 Mouse ; G3V9W2 Rat OMIM: 618999 Human
Documentation	Select Batch: Data Sheet (234 KB) SDS (251 KB) COA (205 KB) User Guide for Antibodies (1077 KB)

JAK1 Antibody (YA331) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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JAK1 Antibody (YA331)

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Biological Activity

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JAK1 Antibody (YA331) Related Classifications

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