ITGB7 Antibody (YA3914)

ITGB7 Antibody (YA3914) is a mouse-derived and non-conjugated IgG1 antibody, targeting to ITGB7. It can be applicated for IHC-P, ICC/IF, FC, ELISA assays, in the background of human.

ITGB7 is a component of integrin ITGA4/ITGB7 (alpha-4/beta-7), also known as Peyer patches-specific homing receptor LPAM-1, which functions as an adhesion molecule mediating lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). It interacts with the cell surface adhesion molecule MADCAM1, expressed by gastrointestinal vascular endothelium, as well as with VCAM1 and the extracellular matrix component fibronectin, recognizing one or more domains within the alternatively spliced CS-1 region of fibronectin. Additionally, ITGB7 forms integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1), acting as a receptor for E-cadherin. In microbial infection, ITGB7 binds to HIV-1 gp120, facilitating viral entry into GALT, which is considered a major trigger for AIDS disease.

P26010

Predicted band size: 87 kDa; Observed band size: 130 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; IF: 1/50-1/200; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human ITGB7 (AA: 20-174) expressed in E. Coli.