Integrin beta 6 Antibody (YA6148)

Integrin beta 6 Antibody (YA6148) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ITGB6. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

The Integrin alpha-V:beta-6 protein (ITGAV:ITGB6) operates as a versatile receptor, recognizing the R-G-D sequence in its ligands such as fibronectin and cytotactin. Additionally, ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1), mediating R-G-D-dependent cell adhesion to FBN1. A crucial role of ITGAV:ITGB6 is highlighted in the mediation of R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from the regulatory Latency-associated peptide (LAP), playing a key role in TGF-beta-1 activation. Structurally, ITGAV:ITGB6 forms a heterodimer, consisting of an alpha and a beta subunit. It interacts with FLNB and HAX1, underscoring its involvement in various cellular processes. Furthermore, ITGAV:ITGB6 interacts with FBN1 and TGFB1, emphasizing its integral role in cell adhesion and the activation of TGF-beta-1 signaling pathways. This diverse range of interactions establishes ITGAV:ITGB6 as a pivotal player in cellular responses and regulatory mechanisms.

P18564

Predicted band size: 86 kDa; Observed band size: 86 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:2000-1:10000; WB: 1:1000-1:5000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200;

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG