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  5. Insulin degrading enzyme Antibody (YA342)

Insulin degrading enzyme Antibody (YA342)

Cat. No.: HY-P80191
User Guide for Antibodies Technical Support

Insulin degrading enzyme Antibody (YA342) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Insulin degrading enzyme.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Insulin degrading enzyme Antibody (YA342) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Insulin degrading enzyme.
Background

IDE (Insulin-Degrading Enzyme) is an enzyme involved in the cellular degradation of various peptides, including insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and others, thereby playing a role in intercellular peptide signaling. Substrate binding induces significant conformational changes, enabling the degradation of larger substrates like insulin. Additionally, IDE contributes to the regulation of peptide hormone signaling cascades and blood glucose homeostasis by degrading insulin, glucagon, and IAPP (by similar). It also participates in the degradation and clearance of APP-derived amyloidogenic peptides secreted by neurons and microglia. IDE degrades natriuretic peptides (ANP, BNP, and CNP), inactivating their ability to elevate intracellular cGMP, and degrades an aberrant frameshifted form of NPPA (fsNPPA) associated with familial atrial fibrillation. Furthermore, IDE is involved in antigen processing, generating both the N- and C-termini of the MAGEA3-derived antigenic peptide (EVDPIGHLY) presented to cytotoxic T lymphocytes via MHC class I. In microbial infections, the membrane-associated isoform of IDE acts as an entry receptor for varicella-zoster virus (VZV).
Tag

Free
Gene ID
SwissProt ID
Molecular Weight

Predicted band size: 118 kDa; Observed band size: 100 kDa
Purity

Protein A affinity purified.
Subcellular Location

Cytoplasm, Cell membrane, Secreted.
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Neuroscience
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse
Dilution Ratio

WB: 1:1,000-1:2,000 ;IHC-P: 1:50-1:200
Application

WB, IHC-P
Appearance

Liquid
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Synthetic peptide corresponding to Human Insulin degrading enzyme.AA range:1-106.
Database

Entrez Gene: 3416 Human ; 25700 Rat

SwissProt: P14735 Human ; Q9JHR7 Mouse ; P35559 Rat

OMIM: 146680 Human

Documentation
User Guide for Antibodies (1077 KB)

Insulin degrading enzyme Antibody (YA342) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Insulin degrading enzyme Antibody (YA342)
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