2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. Hsp70 Antibody (YA728)

Hsp70 Antibody (YA728) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hsp70.

For research use only. We do not sell to patients.

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10 μL In-stock
50 μL In-stock
100 μL In-stock
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Hsp70 Antibody (YA728) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hsp70.
Background

HSP70 is a molecular chaperone involved in a wide range of cellular processes, including protecting the proteome from stress, folding and transporting newly synthesized polypeptides, activating proteolysis of misfolded proteins, and facilitating the formation and dissociation of protein complexes. It plays a central role in the protein quality control system by ensuring proper protein folding, refolding misfolded proteins, and regulating the targeting of proteins for degradation. This function is mediated through cycles of ATP binding, hydrolysis, and ADP release, coordinated by co-chaperones. The affinity of HSP70 for polypeptides is regulated by its nucleotide-bound state: it exhibits low substrate affinity in the ATP-bound form, but undergoes a conformational shift upon ATP hydrolysis to ADP, increasing substrate binding. Repeated cycles of ATP hydrolysis and nucleotide exchange enable substrate binding and release. Additionally, HSP70 positively regulates PRKN translocation to damaged mitochondria.
Tag

Free
Gene ID
SwissProt ID
Molecular Weight

Predicted band size: 70 kDa; Observed band size: 70 kDa
Purity

Immunogen affinity purified.
Subcellular Location

Cytosol, Mitochondrion, Nucleus.
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Signal Transduction

Product Categories

Primary Antibody; Mouse Monoclonal Antibody
Clonality

Monoclonal
Host

Mouse
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:1000-1:2000 ;IF: 1:100-200 ;IHC-P: 1:50-300
Application

WB, IHC-P, ICC/IF
Appearance

Liquid
Formulation

Supplied in 1*PBS ( pH 7.4) and 50% Glycerol. Preservative: 0.02% sodium azide
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Sensitivity

Endogenous
Immunogen

Synthetic Peptide of HSP70
Database

Entrez Gene: 15511 Human ; 3303 Human ; 193740 Mouse ; 3304 Mouse ; 24472 Rat 294254

SwissProt: P0DMV8 Human ; P0DMV9 Human ; P17879 Mouse ; Q61696 Mouse ; P0DMW0 Rat P0DMW1

OMIM: 140550 Human

Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

Hsp70 Antibody (YA728) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Hsp70 Antibody (YA728)
Cat. No.:
HY-P80412
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