hnRNP C1/C2 Antibody (YA5576)

hnRNP C1/C2 Antibody (YA5576) is a mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to hnRNP C1/C2. It can be applicated for WB, ICC/IF, ELISA assays, in the background of human, mouse, rat, monkey, rabbit, orangutan.

hnRNP C1/C2 is an RNA-binding protein that binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. It interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA, modulating the stability and translation efficiency of bound mRNA molecules. A single HNRNPC tetramer binds 230-240 nucleotides, while trimers of HNRNPC tetramers bind 700 nucleotides. This protein may play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Additionally, N6-methyladenosine (m6A) can alter the local structure of mRNAs and long non-coding RNAs (lncRNAs) through an 'm6A-switch' mechanism, facilitating HNRNPC binding and thereby regulating mRNA splicing.

P07910

Predicted band size: 33 kDa; Observed band size: 38,42 kDa

Protein G

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat, Monkey, Rabbit, Orangutan

WB: 1:500-2000; ICC/IF: 1:100-500; ELISA: 1:1000-5000

WB, ICC/IF, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2b

Synthesized peptide derived from human hnRNP C1/2. AA range:200-300