HBcAg Antibody (YA910)

HBcAg Antibody (YA910) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HBcAg.

HBcAg self-assembles to form an icosahedral capsid. Most capsids are large particles with T=4 icosahedral symmetry, composed of 240 copies of the capsid protein, while a smaller fraction forms T=3 particles consisting of 180 capsid proteins. Incoming capsids are transported to the nucleus via microtubules. Phosphorylation of the capsid is believed to expose a nuclear localization signal in its C-terminal region, enabling binding to the nuclear pore complex through importin (karyopherin-) alpha and beta. The capsids are imported intact into the nuclear basket, where they likely interact with NUP153. Only mature capsids containing the viral genome can release viral DNA and capsid proteins into the nucleoplasm, whereas immature capsids remain trapped in the basket. The capsids encapsulate pre-genomic RNA and the P protein. Reverse transcription of pre-genomic RNA into DNA occurs while the capsid is still cytoplasmic. The capsid can then target the nucleus to supply additional genomes for transcription or bud through the endoplasmic reticulum to generate new virions.

P03146

Affinity Chromatography

Non-conjugated

Unmodified

Microbiology

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

IHC: 1:50-1:100

IHC-P

Liquid

Supplied in PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Endogenous

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human HBcAg(NP_647607). The exact sequence is proprietary.