HAO1 Antibody (YA5420)

HAO1 Antibody (YA5420) is a mouse-derived and non-conjugated monoclonal antibody, targeting to HAO1. It can be applicated for WB, IHC-P, ICC/IF, assays, in the background of mouse, rat.

HAO1 Protein exhibits broad substrate specificity as an (S)-2-hydroxy-acid oxidase, with a notable preference for glycolate oxidation. This enzymatic activity generates glyoxylate, a crucial precursor utilized by alanine-glyoxylate aminotransferase in the peroxisomal synthesis of glycine. This pathway plays a vital role in detoxifying glyoxylate, preventing its accumulation, which could otherwise lead to the formation of kidney stones. Additionally, HAO1 can catalyze the oxidation of glyoxylate and long-chain hydroxyacids, such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, albeit with lower catalytic efficiency. While active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), it is believed that O2 serves as the physiological electron acceptor, leading to the production of H2O2. Notably, HAO1 does not exhibit activity on L-lactate and 2-hydroxybutanoate. This multifaceted enzymatic functionality underscores its importance in diverse metabolic pathways.

Q9UJM8

Observed band size: 41 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Mouse, Rat

WB: 1:1000-2000; ICC/IF: 1:200; IHC: 1:50-300

WB, IHC-P, ICC/IF,

Liquid

Supplied in PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Recombinant Protein of HAO1