GRIN2A Antibody (YA4216)

GRIN2A Antibody (YA4216) is a mouse-derived and non-conjugated IgG1 antibody, targeting to GRIN2A. It can be applicated for FC, ELISA assays, in the background of human.

GRIN2A is a component of N-methyl-D-aspartate (NMDA) receptors, which function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg²⁺. These receptors contribute to synaptic plasticity for learning and memory formation by participating in the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similar). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine to the GluN1 subunit, along with membrane depolarization to relieve Mg²⁺ inhibition. NMDA receptors mediate simultaneous potassium efflux and influx of calcium and sodium (By similar). Each GluN2 subunit confers distinct channel properties, including activation, deactivation, and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. GRIN2A participates in synaptic plasticity regulation through activation by L-glutamate released by BEST1 into the synaptic cleft upon F2R/PAR-1 activation in astrocytes (By similar).

Q12879

Predicted band size: 165 kDa; Observed band size: 165 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

FC: 1/200-1/400; ELISA: 1/10000

FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human GRIN2A (AA: extra 23-165) expressed in E. Coli.