Glucocorticoid Receptor Antibody (YA6231)

Glucocorticoid Receptor Antibody (YA6231) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucocorticoid Receptor. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

The Glucocorticoid Receptor (GR) is a receptor for glucocorticoids (GC) with a dual mode of action: functioning as a transcription factor that binds to glucocorticoid response elements (GRE) in both nuclear and mitochondrial DNA, and as a modulator of other transcription factors. It regulates inflammatory responses, cellular proliferation, and differentiation, and is involved in chromatin remodeling. GR also promotes rapid mRNA degradation by binding to target mRNA 5' UTRs and interacting with PNRC2 in a ligand-dependent manner, recruiting UPF1 and DCP1A to induce RNA decay. Additionally, GR acts as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and plays a critical role in hepatic GR-mediated body growth regulation (by similar). GR exhibits both transcriptional activation and repression activities, mediates glucocorticoid-induced apoptosis, and ensures accurate chromosome segregation during mitosis. It may function as a tumor suppressor and negatively regulate adipogenesis by controlling lipolytic and antilipogenic gene expression (by similar). Different isoforms (e.g., Alpha) display varying functions, including transcriptional activity, hormone-binding capacity, and roles in glucose metabolism regulation.

P04150

Predicted band size: 85 kDa; Observed band size: 94 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:1000-1:4000; WB: 1:1000-1:5000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200,

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG