Glucagon Antibody (YA4875)

Glucagon Antibody (YA4875) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Glucagon.

Glucagon is a key hormone in glucose metabolism and homeostasis, regulating blood glucose by increasing gluconeogenesis and decreasing glycolysis. As a counterregulatory hormone to insulin, it raises plasma glucose levels during insulin-induced hypoglycemia and plays a role in initiating/maintaining hyperglycemia in diabetes. It potently stimulates glucose-dependent insulin release and IL6-mediated insulin secretion. Glucagon influences gastric motility, suppresses plasma glucagon levels, and may independently regulate satiety and peripheral glucose disposal. It exhibits growth-promoting effects on intestinal epithelium and potentially modulates the hypothalamic-pituitary axis (HPA) via LH, TSH, CRH, oxytocin, and vasopressin. Additionally, it increases islet mass by stimulating neogenesis and β-cell proliferation while inhibiting apoptosis. by similar: Glucagon-like peptides stimulate intestinal growth, enhance villus height, and promote crypt cell proliferation while reducing enterocyte apoptosis, primarily targeting the gastrointestinal tract from stomach to colon. They improve nutrient assimilation by enhancing gut function and glucose transport while decreasing mucosal permeability. by similar: These peptides also suppress food intake and gastric emptying (potentially increasing satiety via gastric distension) and may modulate gastric acid secretion and gastro-pyloro-duodenal activity, playing a role in early-life intestinal mucosal growth.

P01275

Predicted band size: 21 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human GCG expressed in E. Coli.