GATA6 Antibody (YA5199)

GATA6 Antibody (YA5199) is a mouse-derived and non-conjugated monoclonal antibody, targeting to GATA6. It can be applicated for WB assays, in the background of human.

GATA6 is a transcriptional activator that regulates the expression of SEMA3C and PLXNA2 and is involved in gene regulation specifically in the gastric epithelium, potentially protecting epithelial cells from bacterial infection. In cardiac development, it participates in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression and binds to BMP response element (BMPRE) DNA sequences (By similarity). In human skin, GATA6 controls several physiological processes contributing to the homeostasis of the upper pilosebaceous unit, triggering ductal and sebaceous differentiation while limiting cell proliferation and lipid production to prevent hyperseborrhoea. It mediates the effects of retinoic acid on sebocyte proliferation, differentiation, and lipid production, and contributes to immune regulation and antimicrobial responses by modulating anti-inflammatory (e.g., IL10) and pro-inflammatory (e.g., IL6, TLR2, TLR4, IFNG) gene expression. Additionally, GATA6 activates TGFB1 signaling to regulate interfollicular epidermal fate.

Q92908

Observed band size: 60 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:200

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human GATA6 protein fragments expressed in E.coli.