GATA4 Antibody (YA4030)

GATA4 Antibody (YA4030) is a mouse-derived and non-conjugated IgG2b antibody, targeting to GATA4. It can be applicated for WB, ELISA assays, in the background of human, rat.

GATA4 is a transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function. In cooperation with TBX5, it binds to cardiac super-enhancers to promote cardiomyocyte gene expression while downregulating endocardial and endothelial gene expression. GATA4 is involved in BMP-mediated induction of cardiac-specific gene expression and binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). It acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity) and promotes cardiac myocyte enlargement. GATA4 is required during testicular development and may regulate sphingolipid signaling by controlling the expression of sphingosine-1-phosphate lyase.

P43694

Predicted band size: 45 kDa; Observed band size: 54 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Rat

WB: 1/500-1/2000; ELISA: 1/10000

WB, ELISA

Liquid

Supplied in ascitic fluid containing 0.03% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2b

Purified recombinant fragment of human GATA4 expressed in E. Coli.