GAP-43 Antibody (YA5421)

GAP-43 Antibody (YA5421) is a mouse-derived and non-conjugated monoclonal antibody, targeting to GAP-43. It can be applicated for WB, IHC-P, ICC/IF assays, in the background of human, mouse, rat.

GAP43 protein is intricately associated with nerve growth, emerging as a major component within the motile 'growth cones' that form at the tips of elongating axons. Its pivotal role extends to the induction of axonal and dendritic filopodia, contributing to the dynamic processes crucial for nerve development. Within a molecular context, GAP43 is identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, and CTTN, suggesting its participation in diverse signaling pathways. Additionally, GAP43 exhibits interactions with calmodulin, mediated by its IQ domain, binding calmodulin with greater affinity in the absence of Ca(2+) than in its presence. These intricate molecular associations underscore the multifaceted involvement of GAP43 in nerve growth and signaling cascades, shedding light on its significance in orchestrating axonal dynamics and filopodia formation.

P17677

Observed band size: 38,43 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

WB: 1:1000-2000; IHC: 1:200-500; ICC/IF: 1:50-200

WB, IHC-P, ICC/IF

Liquid

Supplied in PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Recombinant Protein of GAP-43