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  5. GABA A Receptor alpha 1 Antibody (YA1315)

GABA A Receptor alpha 1 Antibody (YA1315)

Cat. No.: HY-P81570
User Guide for Antibodies Technical Support

GABA A Receptor alpha 1 Antibody (YA1315) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1315), targeting GABA A Receptor alpha 1, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). GABA A Receptor alpha 1 Antibody (YA1315) can be used for WB, IHC-P experiment in mouse, rat background.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

GABA A Receptor alpha 1 Antibody (YA1315) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1315), targeting GABA A Receptor alpha 1, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). GABA A Receptor alpha 1 Antibody (YA1315) can be used for WB, IHC-P experiment in mouse, rat background.
Background

GABA A Receptor alpha 1 is the alpha subunit of the heteropentameric ligand-gated chloride channel activated by Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also known as GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore, with GABA active binding sites located at the interface of alpha and beta subunits. Upon GABA activation, GABAARs selectively permit chloride ion flow across the cell membrane along their electrochemical gradient (By similarity). Alpha-1/GABRA1-containing GABAARs are predominantly synaptic (By similarity). Chloride influx into postsynaptic neurons following GABAAR activation reduces their ability to generate new action potentials, thereby inhibiting nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or beta-3 subunits exhibit synaptogenic activity, with the gamma-2 subunit being necessary but not sufficient for rapid synaptic contact formation. GABAARs also function as histamine receptors, where histamine binds at the interface of two neighboring beta subunits, potentiating GABA responses (By similarity). GABAARs composed of alpha, beta, and epsilon subunits allow spontaneous chloride channel activity while maintaining structural integrity for GABA-gated openings (By similarity). Alpha-1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection. Together with rho subunits, it may also modulate neuronal and glial GABAergic transmission in the cerebellum.
Gene ID
SwissProt ID
Synonyms
Gabra1, Gabra-1
Molecular Weight

Predicted band size: 52 kDa; Observed band size:52 kDa
Purity

Protein A purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Neuroscience
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Mouse, Rat
Dilution Ratio

WB：1/500-1/2000，IHC-P：1/50-1/100
Application

WB, IHC-P
Appearance

Liquid
Formulation

Supplied in PBS, Glycerol and BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Peptide
Database

Entrez Gene: 2554 Human ; 14394 Mouse ; 29705 Rat

SwissProt: P14867 Human ; P62812 Mouse ; P62813 Rat

OMIM: 611136 Human

Documentation
User Guide for Antibodies (1077 KB)

GABA A Receptor alpha 1 Antibody (YA1315) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GABA A Receptor alpha 1 Antibody (YA1315)
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