2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. FIP200 Antibody (YA761)

FIP200 Antibody (YA761)

Cat. No.: HY-P80130
COA
SDS
User Guide for Antibodies Technical Support

FIP200 Antibody (YA761) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FIP200.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL In-stock
50 μL In-stock
100 μL In-stock
250 μL   Get quote  
or Bulk Inquiry

* Please select Quantity before adding items.

Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

FIP200 Antibody (YA761) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FIP200.
Background

FIP200 is a multifunctional protein involved in autophagy (PubMed:21775823), regulating both early and late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). During S. typhimurium infection, it contributes to the formation of an autophagosome-like double-membrane structure surrounding the Salmonella-containing vacuole (SCV), facilitating xenophagy (By similarity). Additionally, FIP200 participates in repairing DNA damage caused by ionizing radiation, enhancing cell survival by reducing apoptosis (By similarity). It inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). As a modulator of TGF-beta signaling, FIP200 restricts the substrate specificity of RNF111 (By similarity). It also functions as a DNA-binding transcription factor (PubMed:12095676) and regulates the RB1 pathway by inducing RB1 expression (PubMed:14533007). FIP200 plays critical roles in muscular differentiation (PubMed:12163359), fetal hematopoiesis, and neuronal homeostasis (By similarity).
Tag

Free
Gene ID
SwissProt ID
Molecular Weight

Predicted band size: 183 kDa; Observed band size: 250/150 kDa
Purity

Immunogen affinity purified.
Subcellular Location

Nucleus, Cytoplasm, Cytoplasm, cytosol, Lysosome.
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Signal Transduction
Product Categories

Primary Antibody; Mouse Monoclonal Antibody
Clonality

Monoclonal
Host

Mouse
Reactivity

Human, Mouse
Dilution Ratio

WB: 1:1,000
Application

WB
Appearance

Liquid
Formulation

Supplied in 1*PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG1
Sensitivity

Endogenous
Immunogen

Synthetic peptide corresponding to Human RB1CC1.AA range:651-800.
Database

Entrez Gene: 9821 Human ; 12421 Mouse ; 312927 Rat

SwissProt: Q8TDY2 Human ; Q9ESK9 Mouse ;

OMIM: 606837 Human

Documentation
SDS (251 KB)

COA (191 KB)

User Guide for Antibodies (1077 KB)

FIP200 Antibody (YA761) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
FIP200 Antibody (YA761)
Cat. No.:
HY-P80130
Quantity:
MCE Japan Authorized Agent:

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Country or Region *

Email Address *

     

Phone Number *

 

Organization Name *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.