Fibronectin Antibody (YA436)

Cat. No.: HY-P80493: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

Fibronectin Antibody (YA436) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fibronectin.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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Fibronectin Antibody (YA436) Featured Recommendations:

Publications Citing Use of MCE Fibronectin Antibody (YA436)

•Adv Sci (Weinh). 2025 Jun 23:e05070. [Abstract]

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
Technical Parameters
Properties
Documentation

Description	Fibronectin Antibody (YA436) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fibronectin.
Background	Fibronectin, a versatile glycoprotein, plays a crucial role in cellular interactions by binding to various compounds such as collagen, fibrin, heparin, DNA, and actin. Its involvement in cell adhesion, motility, opsonization, wound healing, and maintenance of cell shape underscores its significance in fundamental cellular processes. Fibronectin also contributes to osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization, and regulates the deposition of type I collagen by osteoblasts. Acting as a ligand for the LILRB4 receptor, Fibronectin inhibits FCGR1A/CD64-mediated monocyte activation. Moreover, Fibronectin's ability to induce fibril formation, as observed in the fibronectin polymer named superfibronectin, imparts enhanced adhesive properties. Notably, both anastellin and superfibronectin exhibit inhibitory effects on tumor growth, angiogenesis, and metastasis, with anastellin activating p38 MAPK and inhibiting lysophospholipid signaling. The multifaceted functions of Fibronectin underscore its pivotal role in cellular dynamics and its potential as a target for therapeutic interventions in various pathological conditions.
Tag	Free
Gene ID	2335 [NCBI]
SwissProt ID	P02751
Molecular Weight	Predicted band size: 272 kDa; Observed band size: 272 kDa
Purity	Protein A affinity purified.
Subcellular Location	Extracellular matrix.
Conjugation	Non-conjugated
Modification	Unmodified
RRID	AB_3102566
Research Field	Cardiovascular
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Mouse
Dilution Ratio	WB: 1:500-1:2,000 ;ICC/IF: 1:100-1:500 ;IHC-P: 1:50-1:200
Application	WB, ICC/IF, IHC-P
Appearance	Liquid
Formulation	Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	Synthetic peptide corresponding to full length protein of Human Fibronectin.AA range:1-2477.
Database	Entrez Gene: 2335 Human ; 14268 Mouse ; SwissProt: P02751 Human ; P11276 Mouse ; P04937 Rat OMIM: 601894 Human
Documentation	Select Batch: Data Sheet (235 KB) SDS (251 KB) COA (191 KB) User Guide for Antibodies (1077 KB)

Fibronectin Antibody (YA436) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Fibronectin Antibody (YA436)

Fibronectin Antibody (YA436) Featured Recommendations:

Publications Citing Use of MCE Fibronectin Antibody (YA436)

Biological Activity

Technical Parameters

Properties

Documentation

Fibronectin Antibody (YA436) Related Classifications

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