Fibulin 5 Antibody (YA4555)

Fibulin 5 Antibody (YA4555) is a mouse-derived and non-conjugated IgG1 antibody, targeting to FBLN5. It can be applicated for IHC-P, ELISA assays, in the background of human.

Fibulin-5 plays a pivotal role in elastic fiber formation, acting as a crucial contributor to the assembly of continuous elastin (ELN) polymers and facilitating the interaction between microfibrils and ELN. This protein is integral to stabilizing and organizing elastic fibers in various tissues such as the skin, lung, and vasculature, demonstrating its significance in maintaining structural integrity. Additionally, Fibulin-5 serves as a vascular ligand for integrin receptors, suggesting its involvement in vascular development and remodeling. By interacting with ELN, integrins, and forming a ternary complex with FBN1, Fibulin-5 acts as an adapter, orchestrating essential molecular interactions that contribute to the proper assembly and function of elastic fibers. The ability of Fibulin-5 to homodimerize in the presence of Ca(2+) further highlights its structural versatility and functional importance in maintaining tissue integrity and elasticity.

Q9UBX5

Predicted band size: 50 kDa; Observed band size: 50 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; ELISA: 1/10000

IHC-P, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of FBLN5 (aa242-448) expressed in E. Coli.