Fas Antibody (YA446)

Fas Antibody (YA446) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fas.

Fas, also known as CD95, serves as a receptor for TNFSF6/FASLG, initiating a cascade of apoptotic events crucial for programmed cell death. The adapter molecule FADD facilitates the recruitment of caspase-8 to the activated receptor, forming the death-inducing signaling complex (DISC) and initiating the cascade of caspases that mediate apoptosis. FAS-mediated apoptosis is implicated in peripheral tolerance induction and the antigen-stimulated suicide of mature T-cells. Additionally, secreted isoforms 2 to 6 of Fas have been identified, which function to block apoptosis in vitro. Fas engages in diverse protein interactions, including DAXX, HIPK3, RIPK1, FAIM2, BABAM2, FEM1B, FADD, NOL3, and CALM, forming a complex network that regulates cell death signaling. The interaction with various molecules highlights the multifaceted roles of Fas in cellular processes, emphasizing its significance in immune regulation and apoptosis modulation.

Free

P25445

Predicted band size: 38 kDa; Observed band size: 40-50 kDa

Protein A affinity purified.

Cell membrane, Secreted.

Non-conjugated

Unmodified

Cell Biology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1:500-1:2,000 ;ICC/IF: 1:50-1:200 ;IHC-P: 1:50-1:200

WB, IHC-P, ICC/IF

Liquid

Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Synthetic peptide corresponding to Human Fas.AA range:130-335.