EphA1 Antibody (YA4828)

EphA1 Antibody (YA4828) is a mouse-derived and non-conjugated monoclonal antibody, targeting to EphA1. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

The EphA1 protein, a receptor tyrosine kinase, engages in promiscuous binding to membrane-bound ephrin-A family ligands on adjacent cells, initiating contact-dependent bidirectional signaling. The downstream pathway originating from the receptor is known as forward signaling, while the pathway downstream of the ephrin ligand is termed reverse signaling. EphA1 exhibits low-affinity binding to EFNA3 and EFNA4 and high-affinity binding to EFNA1, which likely constitutes its cognate/functional ligand. Upon activation by EFNA1, EphA1 induces cell attachment to the extracellular matrix, inhibiting cell spreading and motility through the regulation of ILK and downstream RHOA and RAC. Additionally, EphA1 plays a role in angiogenesis and regulates cell proliferation. It may also be involved in apoptosis processes, contributing to its diverse cellular functions.

P21709

Predicted band size: 108 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; IHC: 1:200-1:1000; ELISA: 1:10000; ICC/IF: 1:50-200

WB, IHC-P, ICC/IF, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of EphA1 expressed in E. Coli.