Drosha Antibody (YA472)

Drosha Antibody (YA472) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Drosha.

Drosha is a double-stranded (ds) RNA-specific endoribonuclease (Ribonuclease III) involved in the initial step of microRNA (miRNA) biogenesis. As a core component of the microprocessor complex, Drosha processes primary miRNA transcripts (pri-miRNAs) in the nucleus to release precursor miRNAs (pre-miRNAs). Within this complex, Drosha cleaves both the 3' and 5' strands of pri-miRNA stem-loops (11 bp from the dsRNA-ssRNA junction) to generate hairpin-shaped pre-miRNAs, which are subsequently processed by cytoplasmic DICER into mature miRNAs. It also participates in pre-rRNA processing, specifically cleaving dsRNA while avoiding ssRNA, and contributes to GW body formation. By similarity, Drosha plays a role in growth homeostasis regulation through autophagy responses in motor neurons.

Free

Q9NRR4

Predicted band size: 159 kDa; Observed band size: 159 kDa

Protein A affinity purified.

Nucleus.

Non-conjugated

Unmodified

AB_3102826

Epigenetics and Nuclear Signaling

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1:500-1:1,000 ;ICC: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

WB, ICC/IF, IHC-P, FC

Liquid

Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Synthetic peptide corresponding to Human Drosha.AA range:30-79.