DOCK8 Antibody (YA2713)

Cat. No.: HY-P82968: Data Sheet User Guide for Antibodies
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DOCK8 Antibody (YA2713) is a non-conjugated IgG antibody, targeting DOCK8, with a predicted molecular weight of 239 kDa (observed band size: 239 kDa). DOCK8 Antibody (YA2713) can be used for WB experiment in human background.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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DOCK8 Antibody (YA2713) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
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Description	DOCK8 Antibody (YA2713) is a non-conjugated IgG antibody, targeting DOCK8, with a predicted molecular weight of 239 kDa (observed band size: 239 kDa). DOCK8 Antibody (YA2713) can be used for WB experiment in human background.
Background	DOCK8 is a guanine nucleotide exchange factor (GEF) that specifically activates the small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:22461490, PubMed:28028151). During immune responses, it is required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Additionally, DOCK8 promotes CD4(+) T-cell migration in response to chemokine stimulation by enhancing CDC42 activation at the T cell leading edge membrane (PubMed:28028151). It also plays a role in NK cell cytotoxicity by controlling microtubule-organizing center (MTOC) polarization and potentially regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).
Gene ID	81704 [NCBI]
SwissProt ID	Q8NF50
Synonyms	MRD2; ZIR8; HEL-205
Molecular Weight	Predicted band size: 239 kDa; Observed band size: 239 kDa
Purity	Affinity Purified
Conjugation	Non-conjugated
Modification	Unmodified
Research Field	Cardiovascular
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human
Dilution Ratio	WB: 1/500-1/1000
Application	WB
Appearance	Liquid
Formulation	Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	Recombinant protein of human DOCK8
Database	Entrez Gene: 81704 Human SwissProt: Q8NF50 Human OMIM: 243700 Human
Documentation	Data Sheet (235 KB) User Guide for Antibodies (1077 KB)

DOCK8 Antibody (YA2713) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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DOCK8 Antibody (YA2713)

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