DMAP1 Antibody (YA2998)

Cat. No.: HY-P83253: Data Sheet User Guide for Antibodies
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DMAP1 Antibody (YA2998) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2998), targeting DMAP1, with a predicted molecular weight of 53 kDa (observed band size: 53 kDa). DMAP1 Antibody (YA2998) can be used for WB, ICC/IF experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

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Description	DMAP1 Antibody (YA2998) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2998), targeting DMAP1, with a predicted molecular weight of 53 kDa (observed band size: 53 kDa). DMAP1 Antibody (YA2998) can be used for WB, ICC/IF experiment in human, mouse, rat background.
Background	DMAP1 is a protein involved in both transcriptional repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following DNA replication at late firing origins. It can repress transcription independently of histone deacetylase activity and may specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. As a component of the NuA4 histone acetyltransferase (HAT) complex, this complex activates transcription of select genes primarily through acetylation of nucleosomal histones H4 and H2A. This modification can alter nucleosome-DNA interactions while promoting interaction between modified histones and other transcription-promoting proteins. The complex is implicated in activating transcriptional programs related to oncogene/proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest, replicative senescence, apoptosis, and DNA repair. When recruited to DNA damage sites, NuA4 may directly participate in DNA repair processes. Additionally, DMAP1 contributes to the nuclear localization of URI1 and enhances its transcriptional corepressor activity.
Gene ID	55929 [NCBI]
SwissProt ID	Q9NPF5
Synonyms	DNA methyltransferase 1 associated protein 1; DNMAP1; DNMTAP1; EAF2; SWC4
Molecular Weight	Predicted band size: 53 kDa; Observed band size: 53 kDa
Purity	Affinity Purified
Conjugation	Non-conjugated
Modification	Unmodified
Research Field	Epigenetics and Nuclear Signaling
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Mouse, Rat
Dilution Ratio	WB: 1/500-1/1000;IF: 1/50-1/200
Application	WB, ICC/IF
Appearance	Liquid
Formulation	Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	A synthesized peptide derived from human DMAP1
Database	Entrez Gene: 55929 Human ; 298447 Rat SwissProt: Q9NPF5 Human ; A2ADW4 Mouse ; Q9JI44 Mouse ; Q568Y6 Rat OMIM: 605077 Human
Documentation	Data Sheet (235 KB) User Guide for Antibodies (1077 KB)

DMAP1 Antibody (YA2998) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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DMAP1 Antibody (YA2998)

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