DDAH2 Antibody (YA1447)

Cat. No.: HY-P81702: Data Sheet COA
SDS
User Guide for Antibodies
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Technical Support

DDAH2 Antibody (YA1447) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DDAH2.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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DDAH2 Antibody (YA1447) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
Technical Parameters
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Documentation

Description	DDAH2 Antibody (YA1447) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DDAH2.
Background	DDAH2 is a putative hydrolase with an unknown substrate (probable). It does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA), which acts as an inhibitor of NOS. In endothelial cells, DDAH2 induces the expression of vascular endothelial growth factor (VEGF) via PKA-mediated phosphorylation of the transcription factor SP1 in a process independent of NO and NO synthase (by similarity). Similarly, it enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (by similarity). Upon viral infection, DDAH2 relocates to mitochondria, where it promotes mitochondrial fission by activating DNM1L, thereby inhibiting MAVS-mediated innate immune response activation.
Gene ID	23564 [NCBI]
SwissProt ID	O95865
Synonyms	DDAH; DDAH II; DDAH2; DDAHII; Dimethylargininase 2; G6a
Molecular Weight	Predicted band size: 30 kDa; Observed band size: 30 kDa
Purity	Affinity Chromatography
Conjugation	Non-conjugated
Modification	Unmodified
RRID	AB_3103809
Research Field	Neuroscience
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Mouse, Rat
Dilution Ratio	WB: 1:500-1:1000; IP: 1:50
Application	WB, IP
Appearance	Liquid
Formulation	Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% Glycerol.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	A synthesized peptide derived from human DDAH2
Database	Entrez Gene: 23564 Human ; 51793 Mouse ; 294239 Rat SwissProt: O95865 Human ; Q99LD8 Mouse ; Q6MG60 Rat OMIM: 604744 Human
Documentation	Select Batch: Data Sheet (234 KB) SDS (251 KB) COA (191 KB) User Guide for Antibodies (1077 KB)

DDAH2 Antibody (YA1447) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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DDAH2 Antibody (YA1447)

DDAH2 Antibody (YA1447) Featured Recommendations:

Biological Activity

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DDAH2 Antibody (YA1447) Related Classifications

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