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  5. CSK Antibody (YA2742)

CSK Antibody (YA2742) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2742), targeting CSK, with a predicted molecular weight of 51 kDa (observed band size: 51 kDa). CSK Antibody (YA2742) can be used for WB, IHC-P experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

CSK Antibody (YA2742) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2742), targeting CSK, with a predicted molecular weight of 51 kDa (observed band size: 51 kDa). CSK Antibody (YA2742) can be used for WB, IHC-P experiment in human, mouse, rat background.
Background

CSK Protein, a non-receptor tyrosine-protein kinase, holds a pivotal role in the intricate regulation of cell growth, differentiation, migration, and immune response. It accomplishes this by phosphorylating tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) such as LCK, SRC, HCK, FYN, LYN, CSK, or YES1. This phosphorylation event induces intramolecular interactions between the phosphotyrosine tail and the SH2 domain of SFKs, resulting in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane through binding to transmembrane proteins or adapter proteins in close proximity. CSK plays a crucial role in suppressing signaling by various surface receptors, including the T-cell receptor (TCR) and B-cell receptor (BCR), by phosphorylating and maintaining several positive effectors such as FYN or LCK in an inactive state, thereby modulating key cellular responses.
Gene ID
SwissProt ID
Synonyms
CSK; Tyrosine-protein kinase CSK; C-Src kinase; Protein-tyrosine kinase CYL
Molecular Weight

Predicted band size: 51 kDa; Observed band size: 51 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
RRID
Research Field

Signal Transduction
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100
Application

WB, IHC-P
Appearance

Liquid
Formulation

Supplied in Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthesized peptide derived from human CSK
Database

Entrez Gene: 1445 Human ; 12988 Mouse ; 315707 Rat

SwissProt: P41240 Human ; P41241 Mouse ; P32577 Rat

OMIM: 124095 Human

Documentation
SDS (251 KB)

COA (191 KB)

User Guide for Antibodies (1077 KB)

CSK Antibody (YA2742) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CSK Antibody (YA2742)
Cat. No.:
HY-P82997
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