CRMP1 Antibody (YA1941)

Cat. No.: HY-P82196: Data Sheet User Guide for Antibodies
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CRMP1 Antibody (YA1941) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1941), targeting CRMP1, with a predicted molecular weight of 62 kDa (observed band size: 64-80 kDa). CRMP1 Antibody (YA1941) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

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Description	CRMP1 Antibody (YA1941) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1941), targeting CRMP1, with a predicted molecular weight of 62 kDa (observed band size: 64-80 kDa). CRMP1 Antibody (YA1941) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.
Background	CRMP1 protein is essential for signaling mediated by class 3 semaphorins, playing a crucial role in the subsequent remodeling of the cytoskeleton. It actively participates in axon guidance, acting downstream of SEMA3A to induce the dissociation of FLNA from F-actin, leading to a reorganization of the actin cytoskeleton and the subsequent collapse of the growth cone. Beyond its role in axon guidance, CRMP1 is implicated in invasive growth and cell migration processes, suggesting its involvement in cellular dynamics. Additionally, there is evidence suggesting its potential contribution to cytokinesis. CRMP1 forms homotetramers and heterotetramers with DPYSL2, DPYSL3, DPYSL4, or DPYSL5, indicating its association with related proteins. Furthermore, it interacts with PLXNA1 and FLNA, specifically through FLNA's calponin-homology (CH) domain 1 and filamin repeat 24, altering FLNA's ternary structure and promoting its dissociation from F-actin, highlighting its intricate involvement in cytoskeletal dynamics.
Gene ID	1400 [NCBI]
SwissProt ID	Q14194
Synonyms	CRMP 1; Crmp1; DPYSL1; DRP1; ULIP-3; Ulip3
Molecular Weight	Predicted band size: 62 kDa; Observed band size: 64-80 kDa
Purity	Affinity Chromatography
Conjugation	Non-conjugated
Modification	Unmodified
Research Field	Neuroscience
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Mouse, Rat
Dilution Ratio	WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200;IP: 1/40;FC: 1/50-1/100
Application	WB, IHC-P, ICC/IF, IP, FC
Appearance	Liquid
Formulation	Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	A synthesized peptide derived from human CRMP1
Database	Entrez Gene: 1400 Human ; 12933 Mouse ; 25415 Rat SwissProt: Q14194 Human ; P97427 Mouse ; Q62950 Rat OMIM: 602462 Human
Documentation	Data Sheet (235 KB) User Guide for Antibodies (1077 KB)

CRMP1 Antibody (YA1941) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CRMP1 Antibody (YA1941)

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