CrkL Antibody (YA4801)

CrkL Antibody (YA4801) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Crk-L. It can be applicated for WB, FC, ELISA assays, in the background of human.

The CRKL protein is implicated in mediating the transduction of intracellular signals, indicating its role in cellular signaling pathways. It interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1, suggesting its involvement in pathways associated with erythropoietin receptor signaling and phosphoinositide signaling. Additionally, CRKL interacts with DOCK2 and DOCK5 via its first SH3 domain, highlighting its potential role in modulating guanine nucleotide exchange factors. The protein further engages with phosphorylated CBLB and IRS4, indicating its participation in pathways related to cellular proliferation and insulin receptor signaling. Furthermore, CRKL interacts with BCAR1/CAS and NEDD9/HEF1, suggesting its involvement in signaling cascades associated with cell adhesion and migration. These diverse interactions underscore the versatility of CRKL in transmitting signals within the cell.

P46109

Predicted band size: 34 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; FC: 1:200-1:400; ELISA: 1:10000

WB, FC, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human Crk-L expressed in E. Coli.