Cortactin Antibody (YA4797)

Cortactin Antibody (YA4797) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Cortactin. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human, mouse.

Cortactin is a protein involved in the organization of the actin cytoskeleton and regulation of cell shape, playing a role in lamellipodia formation and cell migration. Through its interaction with CTTNBP2, it contributes to the regulation of neuronal spine density (By similarity). Additionally, Cortactin functions in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK, it regulates cortical actin-based cytoskeletal rearrangement critical for sphingosine 1-phosphate (S1P)-mediated endothelial cell barrier enhancement. The protein also participates in intracellular protein transport, endocytosis, and modulates the levels of potassium channels at the cell membrane. It is involved in receptor-mediated endocytosis via clathrin-coated pits (By similarity) and stabilizes KCNH1 channels at the cell membrane. Cortactin plays a role in cancer cell invasiveness and metastasis formation.

Q14247

Predicted band size: 62 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse

WB: 1:500-2000; IHC: 1:200-400; IF/ICC1:200-400; ELISA: 1:5000-20000

WB, IHC-P, ICC/IF, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human Cortactin expressed in E. Coli.