Claudin 18.2 Antibody

Cat. No.: HY-P81773: Data Sheet COA
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Claudin 18.2 Antibody is a rabbit-derived non-conjugated IgG antibody, targeting Claudin 18.2, with a predicted molecular weight of 28 kDa. Claudin 18.2 Antibody can be used for WB, IHC-P, ICC/IF, FC experiments in human, mouse, rat backgrounds.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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Claudin 18.2 Antibody Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

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Description	Claudin 18.2 Antibody is a rabbit-derived non-conjugated IgG antibody, targeting Claudin 18.2, with a predicted molecular weight of 28 kDa. Claudin 18.2 Antibody can be used for WB, IHC-P, ICC/IF, FC experiments in human, mouse, rat backgrounds.
Background	Claudin 18 is a protein involved in the regulation of alveolar fluid homeostasis, primarily by modulating the composition of alveolar epithelial tight junctions, thereby influencing ion transport and solute permeability, with potential mechanisms involving downstream regulation of actin cytoskeleton organization and beta-2-adrenergic signaling (by similar). It is essential for lung alveolarization and the maintenance of the paracellular alveolar epithelial barrier (by similar). Additionally, Claudin 18 regulates epithelial progenitor cell proliferation and organ size by controlling YAP1 localization away from the nucleus, thereby restricting YAP1 target gene transcription (by similar). It acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially by relocating TJP2/ZO-2 away from the nucleus, which plays a role in bone resorption during calcium deficiency (by similar). Furthermore, Claudin 18 mediates the osteoprotective effects of estrogen, possibly acting downstream of estrogen signaling independently of RANKL pathways (by similar). In the alveolar microenvironment, it maintains homeostasis by regulating pH and subsequent T-cell activation, indirectly limiting C. neoformans infection. In the stomach, Claudin 18 is required for the formation of the gastric paracellular barrier through its role in tight junction formation, contributing to the response to gastric acidification.
Gene ID	51208 [NCBI]
SwissProt ID	P56856
Synonyms	CLDN 18.2,Claudin 18.2
Molecular Weight	Predicted band size: 28 kDa;Observed band size: 35 kDa
Purity	affinity purified
Conjugation	Non-conjugated
Modification	Unmodified
RRID	AB_3103878
Research Field	Cell Biology
Product Categories	Primary Antibody; Rabbit Polyclonal Antibody
Clonality	Polyclonal
Host	Rabbit
Reactivity	Human, Mouse, Rat
Dilution Ratio	WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:100-1:500;FC: 1:50-1:100;
Application	WB, IHC-P, ICC/IF, FC
Appearance	Liquid
Formulation	Supplied in 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	Synthetic peptide corresponding to N terminal of Human CLDN18.
Database	Entrez Gene: 51208 Human ; 56492 Mouse ; SwissProt: P56856 Human ; P56856-2 Human ; P56857 Mouse ; OMIM: 609210 Human
Documentation	Select Batch: Data Sheet (235 KB) SDS (251 KB) COA (205 KB) User Guide for Antibodies (1077 KB)

Claudin 18.2 Antibody Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Claudin 18.2 Antibody

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