Claudin 18.1 Antibody (YA5683)

Claudin 18.1 Antibody (YA5683) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Claudin 18.1. It can be applicated for IHC-P, ICC/IF, ELISA assays, in the background of human, mouse, rat.

Claudin 18 is a protein involved in the regulation of alveolar fluid homeostasis, primarily by modulating the composition of alveolar epithelial tight junctions, thereby influencing ion transport and solute permeability, with potential mechanisms involving downstream regulation of actin cytoskeleton organization and beta-2-adrenergic signaling (by similar). It is essential for lung alveolarization and the maintenance of the paracellular alveolar epithelial barrier (by similar). Additionally, Claudin 18 regulates epithelial progenitor cell proliferation and organ size by controlling YAP1 localization away from the nucleus, thereby restricting YAP1 target gene transcription (by similar). It acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially by relocating TJP2/ZO-2 away from the nucleus, which plays a role in bone resorption during calcium deficiency (by similar). Furthermore, Claudin 18 mediates the osteoprotective effects of estrogen, possibly acting downstream of estrogen signaling independently of RANKL pathways (by similar). In the alveolar microenvironment, it maintains homeostasis by regulating pH and subsequent T-cell activation, indirectly limiting C. neoformans infection. In the stomach, Claudin 18 is required for the formation of the gastric paracellular barrier through its role in tight junction formation, contributing to the response to gastric acidification.

P56856

Predicted band size: 28 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

IHC: 1:200-400; ICC/IF: 1:50-200; ELISA: 1:500-5000

IHC-P, ICC/IF, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Synthesized peptide derived from human Claudin 18 AA range: 1-100