Claudin 1 Antibody (YA3551)

Cat. No.: HY-P81222A: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

CLDN1 Antibody is an unconjugated, approximately 23 kDa, rabbit-derived, anti-CLDN1 monoclonal antibody. CLDN1 Antibody can be used for: WB, IHC-P expriments in Human, Mouse, Rat background without labeling.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
Technical Parameters
Properties
Documentation

Description	CLDN1 Antibody is an unconjugated, approximately 23 kDa, rabbit-derived, anti-CLDN1 monoclonal antibody. CLDN1 Antibody can be used for: WB, IHC-P expriments in Human, Mouse, Rat background without labeling.
Background	Claudin 1 (CLDN1) is a major component of tight junction complexes that regulate epithelial permeability. Coexpressed and interacting with other claudin family members, it determines overall barrier properties. CLDN1 prevents paracellular diffusion of small molecules in the epidermis and is essential for normal skin barrier function. It maintains water homeostasis indirectly by modulating expression of other proteins (though dispensable for water barrier formation in keratinocyte tight junctions). Additionally, CLDN1 serves as a co-receptor for hepatitis C virus (HCV) by forming the CLDN1-CD81 complex critical for viral entry, and also acts as a receptor for dengue virus.
Gene ID	9076 [NCBI]
SwissProt ID	SwissProt: O95832 Human; SwissProt: O88551 Mouse; SwissProt: P56745 Rat
Synonyms	CLD1_HUMAN; Claudin-1; Claudin 1; Claudin1; CLD1; SEMP1; Senescence-associated epithelial membrane protein; UNQ481/PRO944; ILVASC;
Molecular Weight	Predicted band size: 23 kDa; Observed band size: 19 kDa
Purity	affinity purified
Subcellular Location	Cell junction, tight junction, Cell membrane, Basolateral cell membrane.
Conjugation	Non-conjugated
Modification	Unmodified
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Monoclonal, Recombinant
Host	Rabbit
Reactivity	Human, Mouse, Rat
Dilution Ratio	WB: 1:2,000; IHC-P: 1:500
Application	WB, IHC-P
Positive Control	A431 cell lysate, HUVEC cell lysate, Caco-2 cell lysate, mouse skin tissue lysate, mouse liver tissue lysate, rat skin tissue lysate, rat liver tissue lysate, human esophageal cancer tis
Appearance	Liquid
Formulation	Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Immunogen	Synthetic peptide within Human Claudin 1 aa 164-211 / 211.
Documentation	Select Batch: Data Sheet (234 KB) SDS (251 KB) COA (191 KB) User Guide for Antibodies (1077 KB)

Claudin 1 Antibody (YA3551) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Claudin 1 Antibody (YA3551)

Biological Activity

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Claudin 1 Antibody (YA3551) Related Classifications

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