Clathrin Heavy Chain Antibody (YA6273)

Clathrin Heavy Chain Antibody (YA6273) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Clathrin Heavy Chain.

Clathrin heavy chain is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. It acts as a component of the TACC3/ch-TOG/clathrin complex, which contributes to the stabilization of kinetochore fibers of the mitotic spindle by acting as an inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. It plays a role in early autophagosome formation. Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice, promoting uncoating (by similar).

Q00610

Predicted band size: 192 kDa; Observed band size: 180 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:50-200; WB: 1:500-1:2000; ICC/IF: 1:200-1000; ELISA: 1:5000-20000

WB, IHC-P, ICC/IF, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG