FSP27/CIDEC Antibody (YA911)

FSP27/CIDEC Antibody (YA911) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to FSP27/CIDEC.

CIDEC is a lipid transferase specifically expressed in white adipose tissue, promoting unilocular lipid droplet formation by mediating lipid droplet fusion. This fusion facilitates lipid droplet enlargement, restricting lipolysis and favoring lipid storage. Localized on lipid droplet surfaces and at contact sites between droplets, CIDEC mediates atypical fusion through liquid-liquid phase separation (LLPS), enabling directional net neutral lipid transfer from smaller to larger droplets—a process potentially driven by internal pressure differences between contacting droplets. Its neutral lipid transfer and droplet enlargement functions are activated by interaction with PLIN1. By similarity, CIDEC may also act as a CEBPB coactivator in white adipose tissue to regulate expression of downstream targets like SOCS1, SOCS3, TGFB1, TGFBR1, ID2, and XDH. Overexpression in preadipocytes induces apoptosis or increases susceptibility to apoptosis triggered by serum deprivation or TGFB treatment.

Q96AQ7

Predicted band size: 27 kDa; Observed band size: 27 kDa

Affinity Purified

Nucleus, Endoplasmic reticulum ,Lipid droplet

Non-conjugated

Unmodified

Cell Biology

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:1000; IF: 1:50-1:200; FC: 1:50-1:100

WB, ICC/IF, FC

Liquid

Supplied in PBS with 0.05% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Purified recombinant fragment of human CIDEC expressed in E. Coli.