CHRNB4 Antibody (YA3947)

CHRNB4 Antibody (YA3947) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CHRNB4. It can be applicated for ICC/IF, FC, ELISA assays, in the background of human.

CHRNB4 is a component of neuronal acetylcholine receptors (nAChRs), which function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotransmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAChR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNB4 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3, and CHRNA4, as well as CHRNA5 and CHRNB3 as accessory subunits. CHRNA3:CHRNB4 is predominant in neurons of the autonomic ganglia and is known as the ganglionic nicotinic receptor. Additionally, CHRNA3:CHRNB4 or CHRNA3:CHRNA5:CHRNB4 plays an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (by similar). Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (by similar).

P30926

Predicted band size: 56.4 kDa; Observed band size: 48-60 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IF: 1/100-1/500; FC: 1/200-1/400; ELISA: 1/10000

ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human CHRNB4 (AA: extra 22-236) expressed in E. Coli.