CHRNA6 Antibody (YA4301)

CHRNA6 Antibody (YA4301) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CHRNA6. It can be applicated for IHC-P, ICC/IF, FC, ELISA assays, in the background of human.

CHRNA6 is a component of neuronal acetylcholine receptors (nAChRs), which function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotransmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAChR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (Probable). CHRNA6 forms pentameric channels with CHRNB2, CHRNB3, and CHRNA4 that exhibit high sensitivity to acetylcholine (ACh) and nicotine and are predominantly expressed in only a few brain areas, including dopaminergic neurons, norepinephrine neurons, and cells of the visual system. nAChRs containing CHRNA6 subunits mediate endogenous cholinergic modulation of dopamine and gamma-aminobutyric acid (GABA) release in response to nicotine at nerve terminals.

Q15825

Predicted band size: 57 kDa; Observed band size: 55 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; IF: 1/100-1/500; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human CHRNA6 (AA: 26-239) expressed in E. Coli.