2. Antibodies
  3. Primary Antibodies
  4. Polyclonal Antibodies
  5. CHMP6 Antibody

CHMP6 Antibody is an unconjugated, approximately 23 kDa, rabbit-derived, anti-CHMP6 polyclonal antibody. CHMP6 Antibody can be used for: WB,IHC-P expriments in Human, Mouse background without labeling.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

CHMP6 Antibody is an unconjugated, approximately 23 kDa, rabbit-derived, anti-CHMP6 polyclonal antibody. CHMP6 Antibody can be used for: WB,IHC-P expriments in Human, Mouse background without labeling.
Background

The CHMP6 protein stands as a probable core component of the endosomal sorting required for transport complex III (ESCRT-III), playing a pivotal role in the formation of multivesicular bodies (MVBs) and the sorting of endosomal cargo proteins into these structures. MVBs, containing intraluminal vesicles (ILVs), are vital for the degradation of membrane proteins like growth factor receptors, lysosomal enzymes, and lipids, as they are transported to lysosomes. The MVB pathway involves the sequential function of ESCRT-O, -I, -II, and -III complexes, with ESCRT-III proteins dissociating from the invaginating membrane before ILV release. Notably, CHMP6 is integral to topologically equivalent membrane fission events, participating in the terminal stages of cytokinesis and the budding of enveloped viruses, including HIV-1 and other lentiviruses. Within the ESCRT-III complex, CHMP6 likely serves as an acceptor for the ESCRT-II complex on endosomal membranes, facilitating vesicle extrusion and membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Its interactions with VPS4A, VPS4B, CHMP4A, CHMP4B, CHMP4C, SNF8, VPS25, and VPS36 highlight its intricate involvement in the ESCRT machinery, contributing to various cellular processes.
Gene ID
SwissProt ID
Synonyms
charged multivesicular body protein 6; VPS20
Molecular Weight

Predicted band size: 23 kDa; Observed band size: 23 kDa
Purity

affinity purified
Conjugation

Non-conjugated
Modification

Unmodified
Product Categories

Primary Antibody; Rabbit Polyclonal Antibody
Clonality

Polyclonal
Host

Rabbit
Reactivity

Human, Mouse
Dilution Ratio

WB: 1/500-1/1000; IHC: 1/50-1/100
Application

WB, IHC-P
Appearance

Liquid
Formulation

Supplied in pH 7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

Fusion protein of human CHMP6.
Database

Entrez Gene: 79643 Human ; 208092 Mouse ;

SwissProt: Q96FZ7 Human ; P0C0A3 Mouse ;

OMIM: 610901 Human

Documentation
User Guide for Antibodies (1077 KB)

CHMP6 Antibody Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CHMP6 Antibody
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HY-P83695
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