CENPF Antibody (YA1161)

CENPF Antibody (YA1161) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CENPF.

CENPF is a protein essential for kinetochore function and chromosome segregation during mitosis. It facilitates the localization of dynein, LIS1, NDE1, and NDEL1 to the kinetochore and regulates plasma membrane recycling by linking recycling vesicles to the microtubule network through its association with STX4 and SNAP25. CENPF potentially inhibits pocket protein-mediated cellular processes during development by modulating RB protein activity in cell division and proliferation. It may also play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and promote continued mitosis in abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Additionally, CENPF regulates DNA synthesis and cell cycle progression via its C-terminus and has potential roles in skeletal myogenesis and embryogenic cell differentiation. by similar: It is involved in dendritic cell regulation of T-cell immunity against chlamydia.

P49454

Predicted band size: 358 kDa; Observed band size: 358 kDa

Affinity Purified

Non-conjugated

Unmodified

Epigenetics and Nuclear Signaling

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

IHC: 1:100-1:200

IHC-P

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.267.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Recombinant protein of human CENPF