CDC37 Antibody (YA4310)

CDC37 Antibody (YA4310) is a mouse-derived and non-conjugated IgG2a antibody, targeting to CDC37. It can be applicated for WB, FC, ELISA assays, in the background of human, mouse.

The CDC37 protein serves as a co-chaperone with a pivotal role in facilitating the interaction between numerous kinases and the Hsp90 complex, leading to the stabilization and enhanced activity of these kinases. It functions by inhibiting HSP90AA1 ATPase activity. CDC37 is likely a part of multiple protein complexes, including those containing chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, PPP5C, PTGES3/p23, and client proteins like TSC2, CDK4, AKT, RAF1, and NR3C1. Another complex involving CDC37 comprises chaperones HSP90 and HSP70, co-chaperones PPP5C and TSC1, and client proteins TSC2, CDK4, AKT, RAF1, and NR3C1, but notably lacking STIP1/HOP and PTGES3/p23. CDC37 also forms a distinct complex with Hsp90/HSP90AB1 and CDK6. Its interactions extend to various proteins, including HSP90AA1, AR, CDK4, CDK6, EIF2AK1, RB1, KSR1, and FLCN, FNIP1, and FNIP2. This diverse network of interactions underscores the versatility of CDC37 in regulating the stability and activity of a wide array of kinases and client proteins.

Q16543

Predicted band size: 44 kDa; Observed band size: 50 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Mouse

WB: 1/500-1/2000; FC: 1/200-1/400; ELISA: 1/10000

WB, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2a

Purified recombinant fragment of human CDC37 (AA: 241-378) expressed in E. Coli.