CD96 Antibody (YA3993)

CD96 Antibody (YA3993) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CD96.

CD96 Protein emerges as a potential participant in adhesive interactions during the late phase of the immune response, specifically contributing to the adhesion of activated T and NK cells. Its role in promoting NK cell-target adhesion involves interaction with PVR present on target cells, suggesting a function in the engagement of immune cells with diseased cells during inflammation. The proposed scenario implies that CD96 operates after T and NK cells have traversed the endothelium using integrins and selectins, actively participating in cell-cell interactions within inflamed areas. Structurally, CD96 forms homodimers through disulfide linkages and interacts with PVR, underscoring its potential as a key mediator in immune cell adhesion processes. Further exploration of CD96's precise mechanisms and dynamics in immune responses could provide valuable insights into its role in orchestrating cellular interactions during inflammation and immune surveillance.

P40200

Predicted band size: 66 kDa; Observed band size: 66 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal Antibody

Mouse

Human, Mouse

WB: 1:500-1:2000; FC: 1:200-1:400; ELISA: 1:10000

WB, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2b

Purified recombinant fragment of human CD96 (AA: extra 321-519) expressed in E. Coli.