CD86 Antibody (YA4009)

CD86 Antibody (YA4009) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD86.

CD86 is a receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy within 24 hours after activation. Additionally, it regulates B-cell function, influencing IgG(1) production levels. Upon CD40 engagement, it activates the NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (by similarity). CD86 interferes with its own clustering, acting as a negative regulator of T-cell activation; (Microbial infection) serves as a receptor for adenovirus subgroup B.

P42081

Predicted band size: 38 kDa; Observed band size: 74 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal Antibody

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in ascitic fluid containing 0.03% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment (Aa269-329) of human CD86 expressed in E. Coli.